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Trends Cell Biol. 1993 Jul;3(7):236-41.

Structure, function and assembly of the nucleolus.

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Department of Cell and Developmental Biology, Theodor-Boveri-Institute, University of W├╝rzburg, Germany.


Most events of ribosome biogenesis--such as transcription of the ribosomal RNA (rRNA) genes, processing of their primary transcripts into mature rRNAs and assembly with ribosomal and nonribosomal proteins to form the preribosomes--are confined to a special nuclear compartment, the nucleolus. Immunogold labelling and in situ hybridization at the ultrastructural level are providing novel insights into structure-function relationships of the nucleolus, and in vitro systems are beginning to shed light on the molecular mechanisms involved in the reforming of nucleoli after mitosis.


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