Send to

Choose Destination
See comment in PubMed Commons below
Trends Cell Biol. 1993 Jul;3(7):236-41.

Structure, function and assembly of the nucleolus.

Author information

Department of Cell and Developmental Biology, Theodor-Boveri-Institute, University of W├╝rzburg, Germany.


Most events of ribosome biogenesis--such as transcription of the ribosomal RNA (rRNA) genes, processing of their primary transcripts into mature rRNAs and assembly with ribosomal and nonribosomal proteins to form the preribosomes--are confined to a special nuclear compartment, the nucleolus. Immunogold labelling and in situ hybridization at the ultrastructural level are providing novel insights into structure-function relationships of the nucleolus, and in vitro systems are beginning to shed light on the molecular mechanisms involved in the reforming of nucleoli after mitosis.

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center