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Trends Cell Biol. 1994 Jun;4(6):202-7.

The decision to enter mitosis.

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Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125, USA.


The phosphotyrosine content of the cdc2 protein kinases, the catalytic component of maturation-promoting factor (MPF), is an important parameter of mitotic regulation in a variety of organisms. Recent studies have shed considerable light on how the cdc2-specific tyrosine kinase (wee1) and its competing phosphatase (cdc25) are regulated during the cell cycle. A goal for the future will be to obtain a comprehensive picture of how the wee1-cdc25 regulatory system collaborates with other steps in mitotic activation to ensure that cell division occurs at the appropriate time during the cell cycle.


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