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Trends Cell Biol. 1993 Nov;3(11):381-5.

Profilin as a potential mediator of membrane-cytoskeleton communication.

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MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK CB2 2QH.

Erratum in

  • Trends Cell Biol. 1994;4(1):33.


Profilin, the prototype actin-monomer-sequestering protein, has recently emerged as a multifunctional protein with several different activities. Genetic evidence in yeast and flies confirms that profilin is required for a normal actin cytoskeleton, while biochemical evidence suggests a role in regulating phosphoinositide signalling. New studies suggest that profilin may interact with other ligands, and even its role in regulating actin polymerization is now being re-evaluated.


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