Send to

Choose Destination
Trends Cell Biol. 1994 Oct;4(10):357-65.

Pores for thought: nuclear pore complex proteins.

Author information

Laboratory of Cell Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA.


Nuclear pore complexes (NPCs) are enormous macromolecular structures that mediate the active exchange of proteins and RNPs between the nucleus and cytoplasm. Recent work has resulted in a windfall of identified NPC polypeptides, many with unique sequences. Several of the proteins have been shown to be part of extended cytoplasmic and nucleoplasmic NPC filaments. Biochemical, structural and genetic studies on NPC proteins are just beginning to allow an understanding of how they associate into a functional organelle.

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center