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Trends Cell Biol. 1993 May;3(5):151-5.

hnRNP proteins: localization and transport between the nucleus and the cytoplasm.

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Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Clinical Research Building, Room 328, 422 Curie Boulevard, Philadelphia, PA 19104-6148, USA.


The proteins of heterogeneous nuclear ribonucleoprotein (hnRNP) complexes are among the most abundant proteins in the nucleus. They bind nascent pre-mRNAs and remain associated with them through their nuclear processing into mRNA. Recent findings indicate roles for hnRNP proteins in the biogenesis of mRNA and reveal a surprising intracellular localization pathway for these proteins. Several of the hnRNP proteins shuttle continuously between the nucleus and the cytoplasm, and the reaccumulation of the exported hnRNP proteins in the nucleus occurs by a novel process that is dependent on transcription by RNA polymerase II. These findings suggest possible novel functions for hnRNP proteins in the cytoplasm and in the nucleocytoplasmic transport of mRNA.

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