Send to

Choose Destination
Trends Cell Biol. 1993 Jan;3(1):8-13.

Signalling through SH2 and SH3 domains.

Author information

The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.


In 1986, Pawson's group recognized a region of homology between two oncogenic tyrosine kinases that lay outside the catalytic domain. They termed this the Src homology 2, or SH2, domain. In the ensuing years, SH2 domains have been found in an impressive variety of proteins, as has a second region of homology, inevitably termed SH3. These domains appear to mediate controlled protein-protein interactions. Many proteins that contain SH2 and SH3 domains are involved in signal transduction, suggesting a new paradigm for regulation of intracellular signalling pathways.


Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center