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Trends Cell Biol. 1995 Jan;5(1):32-40.

The cellular responses to DNA damage.

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MRC Cell Mutation Unit, Sussex University, Falmer, Sussex, BN1 9RR, UK.


The ability to survive spontaneous and induced DNA damage, and to minimize the number of heritable mutations that this causes, is essential to the maintenance of genome integrity for all organisms. Early studies on model eukaryotes focused on genes acting in defined DNA repair pathways. More recent work with the budding and fission yeasts and mammalian cells has started to integrate the DNA damage response with cell physiology and the cell cycle.


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