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Trends Cell Biol. 1995 Jan;5(1):27-32.

The relevance of apoptosis to AIDS pathogenesis.

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INSERM U 415, Institut Pasteur, 1 rue du Pr A Calmette, 59019 Lille, France.


Several recent experimental findings support the hypothesis that apoptosis induced by human immune deficiency virus (HIV) is important in the pathogenesis of acquired immune deficiency syndrome (AIDS). Thus, one potential therapeutic strategy against AIDS may be to block the HIV-mediated apoptosis signal transduction pathway. Induction of apoptosis by HIV infection may prove a useful paradigm for the pathogenesis of a wide range of diseases that involve cell depletion and tissue atrophy.


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