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HIV Med. 2004 Jan;5(1):50-4.

Oral candidiasis and seborrheic dermatitis in HIV-infected patients on highly active antiretroviral therapy.

Author information

1
Institute of Dermatovenereology, Clinical Centre of Serbia, Belgrade, Serbia & Montenegro. iva001@eunet.yu

Abstract

BACKGROUND:

Mucocutaneous manifestations such as oral candidiasis (OC) and seborrheic dermatitis (SD) are very common HIV-related opportunistic events and are usually initial markers of immunodeficiency.

AIM:

The purpose of this study was to evaluate the efficacy of highly active antiretroviral therapy (HAART) in the regression of HIV-associated OC and SD.

METHODS:

In a prospective study, 120 HIV-infected patients with OC and SD were divided into two groups: HAART-treated patients (group 1, n=76) and non-HAART-treated patients (group 2, n=44). Non-HAART-treated patients were given antimicrobial therapy. Study subjects were matched for sex, age, risk, and stage of HIV infection. The results were analysed by chi2 test and the Kaplan-Meier method.

RESULTS:

At baseline, OC was evident in 59 (77.7%) of the HAART-treated patients and in 34 (77.3%) of the non-HAART-treated patients, while SD was present in 19 (25.0%) of the HAART-treated patients and in 17 (38.6%) of the non-HAART-treated patients. After a median follow-up period of 22 months, regression of OC and SD occurred in 49 (83.1%) and 16 (84.2%) of the HAART-treated patients, respectively. In the control group, regression of OC and SD occurred in only five (14.7%) and seven (41.2%) patients, respectively, during the same period.

CONCLUSIONS:

HAART showed greater efficacy than standard antimicrobial therapy for the treatment of OC and SD in HIV-infected patients.

PMID:
14731170
[Indexed for MEDLINE]
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