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Trends Biochem Sci. 2004 Jan;29(1):7-10.

Resuscitation-promoting factors possess a lysozyme-like domain.

Author information

1
School of Crystallography and BBRSC Centre for Structural Biology, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, UK.

Abstract

The novel bacterial cytokine family--resuscitation-promoting factors (Rpfs)--share a conserved domain of uncharacterized function. Predicting the structure of this domain suggests that Rpfs possess a lysozyme-like domain. The model highlights the good conservation of residues involved in catalysis and substrate binding. A lysozyme-like function makes sense for this domain in the light of experimental characterization of the biological function of Rpfs.

PMID:
14729326
DOI:
10.1016/j.tibs.2003.10.009
[Indexed for MEDLINE]

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