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Trends Biochem Sci. 2004 Jan;29(1):4-7.

HTTM, a horizontally transferred transmembrane domain.

Author information

1
Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany. Joerg.Schultz@biozentrum.uni-wuerzburg.de

Abstract

Sequence analysis of vitamin K-dependent gamma-carboxylases (VKGC) has revealed the presence of a novel domain, HTTM (for horizontally transferred transmembrane) in its N terminus. In contrast to most known domains, HTTM contains four transmembrane regions. Its occurrence in eukaryotes, bacteria and archaea is probably caused by horizontal gene transfer rather than by early evolution. The conservation of VKGC catalytic sites also indicates an enzymatic function for the other family members.

PMID:
14729325
DOI:
10.1016/j.tibs.2003.11.002
[Indexed for MEDLINE]

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