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Reprod Biol Endocrinol. 2004 Jan 16;2:5.

Androgen receptor expression in the rat prostate is down-regulated by dietary phytoestrogens.

Author information

1
Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA. tlund@colostate.edu

Abstract

BACKGROUND:

It is well established that the growth of the prostate gland is a hormone-dependent phenomenon involving both androgenic and estrogenic control. Proliferation of prostate cells is, at least in part, under control of estrogen receptor beta (ER-beta). Phytoestrogens bind ER-beta with high affinity and therefore may have antiproliferative effects in the prostate.

METHODS:

The prostates of male Long-Evans rats fed a diet high in phytoestrogens (Phyto-600) or very low levels of phytoestrogens (Phyto-free) were analyzed to determine the impact of dietary phytoestrogens on prostate weight and androgen receptor (AR) expression in the prostate.

RESULTS:

Dietary phytoestrogens significantly decreased post-pubertal prostate weight gain in Phyto-600 vs Phyto-free fed males. Additionally, dietary phytoestrogens (Phyto-600) decreased AR expression in the prostate as determined by in situ hybridization.

CONCLUSIONS:

Soy phytoestrogens, present in diet, alter prostate growth presumably by binding ER-beta and subsequently reducing AR expression within the prostate.

PMID:
14728729
PMCID:
PMC340387
DOI:
10.1186/1477-7827-2-5
[Indexed for MEDLINE]
Free PMC Article

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