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J Am Geriatr Soc. 2004 Feb;52(2):274-7.

Clinical phenotype of families with longevity.

Author information

1
Institute for Aging Research, Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Abstract

OBJECTIVES:

To determine whether offspring of centenarians acquired protection from age-related diseases.

DESIGN:

Case-control study.

SETTING:

The study was part of the Longevity Genes Project at Albert Einstein College of Medicine.

PARTICIPANTS:

Centenarians (n=145), offspring of centenarians (n=180), and spouses of the offspring of centenarians (n=75) as a control group. Two additional groups served as controls: age-matched Ashkenazi Jews, and an age-matched control group from the Third National Health and Nutrition Examination Survey.

MEASUREMENTS:

Self-reported family history of longevity; prevalence of hypertension, diabetes mellitus, heart attacks, and strokes; and objective measurements of body mass index and fat mass.

RESULTS:

Parents of centenarians (born in approximately 1870) had a markedly greater ( approximately sevenfold) "risk" for longevity (reaching ages 90-99), supporting the notion that genetics contributed to longevity in these families. The offspring of long-lived parents had significantly lower prevalence of hypertension (by 23%), diabetes mellitus (by 50%), heart attacks (by 60%), and strokes (no events reported) than several age-matched control groups.

CONCLUSION:

Offspring of centenarians may inherit significantly better health. The authors suggest that a cohort of these subjects and their spouses is ideal to study the phenotype and genotype of longevity and its interaction with the environment.

PMID:
14728640
[Indexed for MEDLINE]
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