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EMBO Rep. 2004 Feb;5(2):201-6. Epub 2004 Jan 9.

Yeast N-glycanase distinguishes between native and non-native glycoproteins.

Author information

1
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

N-glycanase from Saccharomyces cerevisiae (Png1) preferentially removes N-glycans from misfolded proteins. The ability of Png1 to distinguish between folded and misfolded glycoproteins is reminiscent of substrate recognition by UDP-glucose glycoprotein glucosyl transferase, an enzyme that possesses this trait. The only known in vivo substrates of Png1 are aberrant glycoproteins that originate in the endoplasmic reticulum, and arrive in the cytoplasm for proteasomal degradation. The substrate specificity of Png1 is admirably suited for this task.

PMID:
14726951
PMCID:
PMC1298977
DOI:
10.1038/sj.embor.7400066
[Indexed for MEDLINE]
Free PMC Article
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