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Ann Thorac Surg. 2004 Jan;77(1):363-71.

Drug immunosuppression therapy for adult heart transplantation. Part 2: clinical applications and results.

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1
Department of Cardiovascular Surgery, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada. xavier.mueller@usherbrooke.ca

Abstract

This review describes the clinical application of classical immunosuppressive drugs as well as that of more recent drugs. All current immunosuppressive drugs target T-cell activation, and cytokine production and clonal expansion, or both. Immunosuppressive protocols can be broadly divided into induction therapy, maintenance immunosuppression, and treatment of acute rejection episodes.

PMID:
14726105
[Indexed for MEDLINE]
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