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Int Dent J. 2003 Dec;53(6 Suppl 1):391-7.

The effect of a toothpaste containing 2% zinc citrate/0.3% Triclosan on the glycolysis of plaque bacteria ex vivo after food intake.

Author information

1
Unilever Oral Care, Quarry Road East, Bebington, Wirral, UK. suzi.adams@unilever.com

Abstract

OBJECTIVE:

To develop an ex vivo plaque pH method to assess the efficacy of a new zinc citrate/Triclosan formulation.

METHODS:

Study (1) focussed on method development. Study (2) examined the effect of a toothpaste containing 2% zinc citrate/0.3% Triclosan on the pH of plaque after product use and consumption of pizza. Study (3) investigated the effect of the same formulation and a fluoride toothpaste on the pH of plaque without an 'eating occasion'. The pH of plaque samples was measured over 10 minutes in the presence of glucose.

RESULTS:

The test product significantly reduced the amount of acid produced 30 minutes (p = 0.0035) and 3 hours (p = 0.0018) after brushing (study (2)). In study (3) use of the test product significantly reduced the amount of acid produced 3 hours after brushing (p = 0.0023). No significant benefit was found for the fluoride toothpaste.

CONCLUSION:

An ex vivo plaque pH method has been developed which can detect changes in acid produced following brushing with different toothpastes. A toothpaste containing 2% zinc citrate/0.3% Triclosan significantly reduced the total acid produced for at least 3 hours after product use. Moreover it has been demonstrated that this effect is detectable even after eating.

[Indexed for MEDLINE]

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