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Di Yi Jun Yi Da Xue Xue Bao. 2004 Jan;24(1):57-8.

[Experimental study of the effect of Astragalus membranaceus against herpes simplex virus type 1].

[Article in Chinese]

Author information

1
Department of Pharmaceutics, General Hospital of PLA, Beijing 100853, China.

Abstract

OBJECTIVE:

To study the inhibitory effects of Astragalus membranaceus on herpes simplex virus type 1(HSV-1).

METHODS:

In the 2BS cells infected with HSV-1, the antiviral effect of Astragalus membranaceus decoction was investigated by observing the inhibition of HSV-1-induced cytopathic effect in response to treatment with the decoction.

RESULTS:

The half inhibition concentration (IC50) and minimal inhibition concentration (MIC) of Astragalus membranaceus were 0.98 and 1.95 g/ml respectively, with the therapeutic index (TI) of 128.

CONCLUSION:

Astragalus membranaceus has obvious HSV-1-inhibiting efficacy and low cytotoxicity.

PMID:
14724098
[Indexed for MEDLINE]
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