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J Clin Invest. 2004 Jan;113(2):175-9.

Bmi1, stem cells, and senescence regulation.

Author information

1
Department of Internal Medicine, University of Michigan, School of Medicine, Ann Arbor, 48109, USA.

Abstract

Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.

PMID:
14722607
PMCID:
PMC311443
DOI:
10.1172/JCI20800
[Indexed for MEDLINE]
Free PMC Article

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