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J Clin Invest. 2004 Jan;113(2):148-57.

Disorders of lung matrix remodeling.

Author information

1
Department of Medicine and Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94143-0130, USA. halchap@itsa.ucsf.edu

Abstract

A set of lung diseases share the tendency for the development of progressive fibrosis ultimately leading to respiratory failure. This review examines the common pathogenetic features of these disorders in light of recent observations in both humans and animal models of disease, which reveal important pathways of lung matrix remodeling.

PMID:
14722604
PMCID:
PMC311438
DOI:
10.1172/JCI20729
[Indexed for MEDLINE]
Free PMC Article

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