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Protein Sci. 2004 Feb;13(2):545-8. Epub 2004 Jan 10.

Solution structure of a BolA-like protein from Mus musculus.

Author information

1
Protein Research Group, RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan.

Abstract

The BolA-like proteins are widely conserved from prokaryotes to eukaryotes. The BolA-like proteins seem to be involved in cell proliferation or cell-cycle regulation, but the molecular function is still unknown. Here we determined the structure of a mouse BolA-like protein. The overall topology is alphabetabetaalphaalphabetaalpha, in which beta(1) and beta(2) are antiparallel, and beta(3) is parallel to beta(2). This fold is similar to the class II KH fold, except for the absence of the GXXG loop, which is well conserved in the KH fold. The conserved residues in the BolA-like proteins are assembled on the one side of the protein.

PMID:
14718656
PMCID:
PMC2286707
DOI:
10.1110/ps.03401004
[Indexed for MEDLINE]
Free PMC Article

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