Format

Send to

Choose Destination
Stat Med. 2004 Jan 30;23(2):351-67.

Managing and analysing data from a large-scale study on Framingham Offspring relating brain structure to cognitive function.

Author information

1
Department of Biostatistics, Boston University School of Public Health, 715 Albany Street T3E, Boston, MA 02118, USA. jmm@bu.edu

Abstract

At the Framingham Heart Study under separate research grant funding from the National Institute of Aging, NIH, we are gathering brain structure and cognitive information on the Framingham Offspring, creating one of the largest known data sets to assess changes in brain structure associated with normative ageing and cognitive decline. Subject recruitment, data collection, data management and statistical analysis require a collaborative integrated effort on the part of the Framingham project team. Here we describe this effort, as well as the various brain structure and cognitive function parameters we are now collecting. We are currently performing analyses of data collected through 2002, and we discuss the statistical issues arising relating brain structure parameters to cognitive function.

PMID:
14716734
DOI:
10.1002/sim.1743
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center