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Am J Cardiol. 2004 Jan 15;93(2):219-20.

Effect of Helicobacter pylori eradication on high-density lipoprotein cholesterol.

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Clinical Institute of Medical and Chemical Laboratory Diagnostics, University and General Hospital, University of Graz, Graz, Austria.


We examined the effect of Helicobacter pylori (H. pylori) eradication on lipids and apolipoproteins in 87 patients with duodenal ulcers. A significant increase was observed in high-density lipoprotein (HDL) cholesterol (+24.7%, p <0.001), apolipoprotein AI (+9.0%, p <0.001), and apolipoprotein AII (+11.7%, p <0.001) after eradication. Minor increases occurred in total cholesterol, triglycerides, and apolipoprotein B, whereas low-density lipoprotein cholesterol remained unchanged. Our results suggest that chronic H. pylori infection reduces plasma levels of HDL cholesterol and that eradication improves the lipoprotein pattern.

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