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Am J Public Health. 2004 Jan;94(1):136-40.

Maternal smoking in pregnancy, fetal development, and childhood asthma.

Author information

1
Institute of Occupational Health, The University of Birmingham, Birmingham, United Kingdom. j.jaakkola@bham.ac.uk

Abstract

OBJECTIVES:

We examined the relationships among maternal smoking in pregnancy, fetal development, and the risk of asthma in childhood.

METHODS:

We conducted a population-based cohort study, where all 58 841 singleton births were followed for 7 years using nationwide registries.

RESULTS:

Maternal smoking increased the risk of asthma (adjusted odds ratio = 1.35; 95% confidence interval = 1.13, 1.62 for high exposure). Low birthweight and preterm delivery increased the risk of asthma at the age of 7, whereas being small for gestational age did not.

CONCLUSIONS:

Maternal smoking in pregnancy increases the risk of asthma during the first 7 years of life, and only a small fraction of the effect seems to be mediated through fetal growth.

PMID:
14713711
PMCID:
PMC1449839
[Indexed for MEDLINE]
Free PMC Article

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