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Cell Cycle. 2004 Feb;3(2):138-40.

To be or not to be ubiquitinated?

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1
Department of Pathology and NYU Cancer Institute, New York University School of Medicine, New York, New York 10016, USA.

Abstract

Levels of p21, a cyclin-dependent kinase (CDK) inhibitor, are controlled in part at the post-translational level by protein degradation. Although the signaling pathways leading to p21 degradation have not yet been fully elucidated, it is evident that p21 ubiquitination is an essential factor in its degradation. We discuss that, with the only notable exception of ornithine decarboxylase, ubiquitination appears to be a prerequisite for proteasomal degradation rather than an unnecessary byproduct of such proteolysis.

PMID:
14712075
[Indexed for MEDLINE]
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