Format

Send to

Choose Destination
See comment in PubMed Commons below
Ophthalmology. 2004 Jan;111(1):109-11.

Topiramate-associated acute, bilateral, secondary angle-closure glaucoma.

Author information

1
The Casey Eye Institute, Oregon Health & Science University, Portland, Oregon 97201, USA. fraunfer@ohsu.edu

Abstract

PURPOSE:

To evaluate spontaneous reports of ocular side effects associated with topiramate use.

DESIGN:

Retrospective case series.

METHODS:

One hundred fifteen case reports, primarily of a specific ocular syndrome (acute secondary angle-closure glaucoma), were collected from spontaneous reporting systems: the Drug Safety section of Ortho-McNeil Pharmaceuticals, Inc. (Raritan, NJ), the Food and Drug Administration (Rockville, MD), the World Health Organization (Uppsala, Sweden), the National Registry of Drug-Induced Side Effects (Casey Eye Institute, Oregon Health & Science University, Portland, Oregon), and the world literature.

MAIN OUTCOME MEASURES:

The data were evaluated using the World Health Organization Causality Assessment Guide to the certainty of a suspected adverse drug reaction.

RESULTS:

Eighty-six cases of acute-onset glaucoma (83 bilateral and 3 unilateral), 17 cases of acute bilateral myopia (up to 8.75 diopters), 9 cases of suprachoroidal effusions, 3 cases of periorbital edema, and 4 cases of scleritis were reported. In those cases for which management was reported, 38% had laser or surgical peripheral iridectomy (21 cases).

CONCLUSIONS:

In the "certain" category of the World Health Organization classification system, the following are caused by topiramate therapy: abnormal vision, acute secondary angle-closure glaucoma, acute myopia, and suprachoroidal effusions. All findings are reversible if recognized early and if the drug is discontinued. The first presenting symptom of acute secondary angle-closure glaucoma in many patients was blurring of vision. Peripheral iridectomy is ineffective for this type of angle-closure glaucoma.

PMID:
14711721
DOI:
10.1016/j.ophtha.2003.04.004
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center