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Adv Immunol. 2003;81:199-252.

HLA-G molecules: from maternal-fetal tolerance to tissue acceptance.

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Service de Recherches en Hémato-Immunologie, Direction des Sciences du Vivant, Département de Recherche Médicale, CEA Commissariat à l'Energie Atomique, Institut Universitaire d'Hématologie, Hôpital Saint-Louis, 75010 Paris, France.


Over the past few years, HLA-G, the non-classical HLA class I molecule, has been the center of investigations that have led to the description of its specific structural and functional properties. Although located in the HLA class I region of chromosome six, the HLA-G gene may be distinguished from other HLA class I genes by its low polymorphism and alternative splicing that generates seven HLA-G proteins, whose tissue-distribution is restricted to normal fetal and adult tissues that display a tolerogeneic function toward both innate and acquired immune cells. We review these points, with special emphasis on the role of HLA-G in human pathologies, such as cancer, viral infection, and inflammatory diseases, as well as in organ transplantation.

[Indexed for MEDLINE]

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