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Avian Dis. 2003 Oct-Dec;47(4):1376-83.

Immunization of turkeys with a DNA vaccine expressing either the F or N gene of avian metapneumovirus.

Author information

1
Laboratory, Agricultural Research Service, Southeast Poultry Research United States Department of Agriculture, 934 College Station Road, Athens, GA 30605, USA.

Abstract

In this study we compared protection by DNA vaccination with the F (pCMV-F) or N (pCMV-N) gene from avian metapneumovirus (aMPV) in turkeys. One-week-old turkey poults received two intramuscular injections 2 wk apart. Birds were challenged with a turkey-embryo-adapted aMPV at 5 wk of age. Birds vaccinated with pCMV-F had decreased clinical signs of disease as well as significantly reduced virus load in tracheal swabs compared with birds vaccinated with pCMV-N or unvaccinated control birds. Serum neutralizing antibodies were significantly higher in birds receiving pCMV-F compared with all other groups. These results indicate that DNA vaccination with the F, but not N, gene of aMPV can induce significant protection against aMPV infection.

PMID:
14708985
DOI:
10.1637/7033
[Indexed for MEDLINE]

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