The retinal electrogenesis was studied in central chorioretinal dystrophy (CCRD) of different stages. The general peculiarities of the ozone-therapy influence on the functional retinal activity typical of any CCRD stage were detected; they comprise: an increasing activity of neurons in the muscular region and a specificity related with the dynamic functional activity of the retinal peripheral segments peculiar of each disease stage. A sharp growth of glial index Cg (b/R12) detected in all patients is indicative of an activated metabolism of Mueller glial cells and of impaired glial-neuron relations in the retina as observed in CCRD. A decreasing Cg, observed after ozone-therapy, is an indirect confirmation of anti-hypoxic effect produced by ozone, which can be regarded as a patho-physiological mechanism of its positive influence on the dynamics of the functional retinal activity. Ozone-therapy is recommended to be implemented with the electroretinography monitoring.