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Nat Rev Mol Cell Biol. 2004 Jan;5(1):55-63.

Tubby proteins: the plot thickens.

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Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, Room 712, New York, New York 10032, USA.


The tubby mouse, which shows late-onset obesity and neurosensory deficits, arises from a mutation in the Tub gene. Tub shares homology with the genes for tubby-like proteins Tulp1, Tulp2 and Tulp3. Ablation of Tub, Tulp1 or Tulp3 causes disease phenotypes that are indicative of their importance in nervous-system function and development. Despite this importance, the biochemical functions of tubby-like proteins are only now beginning to be understood. At present, data indicate that tubby-like proteins might function as heterotrimeric-G-protein-responsive intracellular signalling factors, although an array of data also implicates them in other processes.

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