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Nat Rev Mol Cell Biol. 2004 Jan;5(1):33-44.

Regulation of the c-Abl and Bcr-Abl tyrosine kinases.

Author information

1
Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. hantschel@embl-heidelberg.de

Abstract

The prototypic non-receptor tyrosine kinase c-Abl is implicated in various cellular processes. Its oncogenic counterpart, the Bcr-Abl fusion protein, causes certain human leukaemias. Recent insights into the structure and regulation of the c-Abl and Bcr-Abl tyrosine kinases have changed the way we look at these enzymes.

PMID:
14708008
DOI:
10.1038/nrm1280
[Indexed for MEDLINE]

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