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J Neurol Neurosurg Psychiatry. 2004 Jan;75(1):152-4.

Chlamydophila pneumoniae infection of the central nervous system in patients with multiple sclerosis.

Author information

1
Microbiology Department, University College London Hospitals, London WC1E 6DB, UK. SFurrows@aol.com

Abstract

BACKGROUND:

Chlamydophila pneumoniae has been postulated as an aetiological agent in the pathophysiology of multiple sclerosis. Previous studies show conflicting results.

OBJECTIVE:

To investigate patients with multiple sclerosis and other neurological diseases for evidence of past or present infection with C pneumoniae.

METHODS:

19 patients with multiple sclerosis and 29 with other neurological diseases were studied. Evidence was sought for past or present infection with C pneumoniae using polymerase chain reaction (PCR) and cell culture of cerebrospinal fluid (CSF), and enzyme linked immunosorbent assay and microimmunofluorescence of serum.

RESULTS:

C pneumoniae was grown from the CSF of one patient with multiple sclerosis. PCR was negative in all cases. Anti-chlamydial antibodies were detected in the same proportion in each group.

CONCLUSIONS:

This study does not support the theory of an association between C pneumoniae and multiple sclerosis.

PMID:
14707329
PMCID:
PMC1757474
[Indexed for MEDLINE]
Free PMC Article

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