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J Immunol. 2004 Jan 15;172(2):752-6.

Cutting edge: NF-kappa B2 is a negative regulator of dendritic cell function.

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  • 1Department of Pathobiology, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA.


RelB, a member of the NF-kappaB family of transcription factors, is essential for dendritic cell (DC) maturation. Recent findings indicate that RelB is exclusively regulated through its interaction with cytoplasmic NF-kappaB2/p100. The studies presented in this report show that DCs lacking NF-kappaB2 have dramatically enhanced RelB activity, associated with increased MHC class II and costimulatory molecule expression and an enhanced ability to induce CD4(+) T cell responses. These studies identify a novel role for NF-kappaB2 in the negative regulation of RelB-induced DC maturation, with critical consequences for the regulation of adaptive immune responses.

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