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J Microbiol Methods. 2004 Jan;56(1):137-9.

Simple table for estimating confidence interval of discrepancy frequencies in microbiological safety evaluation.

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  • 1Laboratoire de bact√©riologie, Centre hospitalier Lyon-sud, Hospices Civils de Lyon F-69495 Pierre Benite Cedex, France.


We provide a simple tool to determine discrepancies confidence interval (CI) in microbiology validation studies such as technical accuracy of a qualitative test result. This tool enables to determine exact confidence interval (binomial CI) from an observed frequency when normal approximation is inadequate, that is, in case of rare events. This tool has daily applications in microbiology and we are presenting an example of its application to antimicrobial susceptibility systems evaluation.

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