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Genomics. 2004 Feb;83(2):332-4.

Target-selected mutagenesis of the rat.

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1
Functional Genomics Group, Centre for Biomedical Genetics, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

Abstract

The rat is one of the most extensively studied model organisms, and with its genome being sequenced, tools to manipulate gene function in vivo have become increasingly important. We here report proof of principle for target-selected mutagenesis as a reverse genetic or knockout approach for the rat.

PMID:
14706462
[Indexed for MEDLINE]
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