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Int J Eat Disord. 2004 Jan;35(1):16-26.

Clinical trial of sertraline in the treatment of night eating syndrome.

Author information

1
Department of Psychiatry, Weight and Eating Disorders Program, University of Pennsylvania, Philadelphia, 19104, USA. oreardon@mail.med.upenn.edu

Abstract

OBJECTIVE:

To test the efficacy of sertraline in the treatment of night eating syndrome.

METHODS:

Seventeen patients meeting criteria for night eating syndrome received sertraline in a 12-week open-label, nonblind trial. Outcome was assessed by four primary measures, namely, the number of nocturnal awakenings, the number of ingestions, total daily caloric intake after the evening meal, and an overall rating of change from the Clinical Global Impression of Improvement scale (CGI-I).

RESULTS AND DISCUSSION:

An intent-to-treat analysis revealed highly significant improvements across all four primary outcome measures for all 17 subjects. Five subjects achieved full remission of symptoms (CGI-I score of 1 = very much improved) and lost a significant amount of weight over the course of the study (-4.8 +/- 2.6 kg, p < .05). Sertraline, a selective serotonin reuptake inhibitor, may be beneficial in the treatment of night eating syndrome.

PMID:
14705153
DOI:
10.1002/eat.10224
[Indexed for MEDLINE]

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