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Ann Neurol. 2004 Jan;55(1):113-8.

DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia.

Author information

1
Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.

Abstract

Two novel mutations recently have been identified in the DJ-1 gene that cause a new form of autosomal recessive, early-onset parkinsonism. Because the pathological role of this protein is unknown, we examined the issue here and report the colocalization of DJ-1 protein within a subset of pathological tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Our study extends the view that different neurodegenerative diseases may have similar pathological mechanisms, and that these processes likely include DJ-1.

PMID:
14705119
DOI:
10.1002/ana.10782
[Indexed for MEDLINE]

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