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Nat Cell Biol. 2004 Jan;6(1):3-7.

Controlling Abl: auto-inhibition and co-inhibition?

Author information

1
Section of Molecular Biology, Division of Biological Sciences and the Cancer Center, University of California, San Diego, La Jolla, CA 92093-0322, USA. jywang@ucsd.edu

Abstract

Auto-inhibition describes the capacity of proteins to adopt a self-imposed latent conformation. Recently, a crystal structure of the Abl tyrosine kinase has revealed its ability to auto-inhibit. However, a separate body of work suggests that other cellular proteins also inhibit Abl. To reconcile the crystal structure with Abl inhibitors, I propose that Abl is controlled by cellular 'co-inhibitors' that bind Abl, stabilizing the auto-inhibited conformation. The implication of co-inhibition on Abl function is discussed.

PMID:
14704671
DOI:
10.1038/ncb0104-3
[Indexed for MEDLINE]

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