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Genetics. 2003 Dec;165(4):2295-9.

A Sod2 null mutation confers severely reduced adult life span in Drosophila.

Author information

1
Biology Department, Howard University, Washington, DC 20059, USA. aduttaroy@howard.edu

Abstract

A null mutation for the Sod2 gene, Sod2n283, was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodn283/Sodn283) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2-/- progeny suffer neonatal lethality. Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.

PMID:
14704205
PMCID:
PMC1462872
[Indexed for MEDLINE]
Free PMC Article

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