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Am J Perinatol. 2003 Nov;20(8):485-90.

Vitamin K prophylaxis for premature infants: 1 mg versus 0.5 mg.

Author information

1
Division Neonatology, Franciscan Skemp-Mayo Health System, La Crosse, Wisconsin 54601, USA. Costakos.Donald@mayo.edu

Abstract

We studied babies (22 to 32 weeks gestational age) of mothers wishing to breast-feed. Group 1 received 1 mg of vitamin K and Group 2 received 0.5 mg of vitamin K. The Day 2 plasma levels of vitamin K were 1900 to 2600 times higher on average, and the Day 10 vitamin K levels 550 to 600 times higher on average, relative to normal adult plasma values, whether an initial prophylaxis dose of 0.5 mg or 1 mg was used. We conclude that 0.5 mg as the initial dose of vitamin K intramuscularly or intravenously would likely be more than adequate to prevent hemorrhagic disease of the newborn, and that 0.3 mg/per kg may be used for babies with birth weights below 1000 g. To decrease vitamin K intakes in this population, new preparations of total parenteral nutrition multivitamins are needed.

PMID:
14703597
DOI:
10.1055/s-2003-45384
[Indexed for MEDLINE]

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