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J Neuroimmunol. 2004 Jan;146(1-2):46-9.

Proximity between 5-HT secreting enteroendocrine cells and lymphocytes in the gut mucosa of rhesus macaques (Macaca mulatta) is suggestive of a role for enterochromaffin cell 5-HT in mucosal immunity.

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1
Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA.

Abstract

The involvement of serotonin (5-hydroxytryptamine; 5-HT) in immunoregulation has been well documented. Gut mucosa is a large reservoir of 5-HT most of which is attributed to gut endocrine cells. In this study, we examined the anatomical relationship among 5-HT immunoreactive cells and T and B lymphocytes in the gut mucosa of rhesus monkeys (Macaca mulatta). 5-HT, CD3 and CD20 immunoreactive cells were immunofluorescently labeled and visualized by confocal microscopy. 5-HT immunoreactive cells were primarily found within the epithelium of the intestine and were present at all levels of the gastrointestinal tract. Many 5-HT immunoreactive cells were in contact with, or very close proximity to CD3(+) and CD20(+) lymphocytes. These results provide morphological evidence to suggest interactions between 5-HT secreting enteroendocrine cells and lymphocytes in the gut mucosa. This further supports a possible role of 5-HT in mucosal immune responses.

PMID:
14698846
DOI:
10.1016/j.jneuroim.2003.10.044
[Indexed for MEDLINE]

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