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Epilepsy Behav. 2003 Dec;4(6):740-5.

A retrospective analysis of the effects of magnet-activated stimulation in conjunction with vagus nerve stimulation therapy.

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Regional Epilepsy Center, 2801 West Kinnickinnic River Parkway, Suite 570, 53215, Milwaukee, WI, USA.


Vagus nerve stimulation (VNS) therapy offers two methods to help control seizures, automatic stimulation delivered at programmed intervals and on-demand stimulation initiated with a magnet. This study retrospectively analyzes magnet use during the E03 and E04 clinical trials of VNS therapy. Magnet activation that aborted, decreased, terminated, or diminished a seizure was classified as an improvement; for purposes of evaluation, the patient was considered to have received a benefit. When patients in the E03 trial used magnets to activate stimulation, patients with active magnets were more likely to report seizure improvement than patients with inactive magnets (P=0.0479, Fisher's test). In the E04 trial, 22% of patients using the magnet reported seizure termination and 31% reported seizure diminution. Unrelated to seizure reduction with programmed VNS therapy, approximately half of the patients who used the magnet in this study received some benefit. Additional studies can provide a better understanding of this unique mode of delivering antiseizure therapy.

[Indexed for MEDLINE]

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