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Bioorg Med Chem Lett. 2004 Jan 19;14(2):409-12.

A novel series of potent and selective IKK2 inhibitors.

Author information

1
Celltech R&D Ltd, Granta Park, Great Abington, CB16GS, Cambridge, UK.

Abstract

A novel series of aminopyrimidine IKK2 inhibitors have been developed which show excellent in vitro inhibition of this enzyme and good selectivity over the IKK1 isoform. The relative potency and selectivity of these compounds has been rationalized using QSAR and structure-based modelling.

PMID:
14698170
DOI:
10.1016/j.bmcl.2003.10.047
[Indexed for MEDLINE]

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