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Transplant Proc. 2003 Dec;35(8):3003-5.

Living related liver transplantation in 13 cases of progressive familial intrahepatic cholestasis.

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Department of Surgery, Riyadh Armed Forces Hospital, Riyadh 11159, Kingdom of Saudi Arabia.


Progressive familial intrahepatic cholestasis (PFIC) is a heterogenous group of disorders with various etiologies. Recent molecular and genetic studies have categorized the spectrum of types. Liver transplantation is a curative modality of treatment in this disease. We report our experience with 13 patients with PFIC who underwent living related liver transplantation. The follow-up periods ranged from 12 to 50 months. Two children died at 1 and 2 years posttransplantation, leading to a decrease in survival rate from 100% in the first year to 84.6%.

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