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Mol Cell Neurosci. 2003 Dec;24(4):1116-30.

Constitutive EGFR signaling confers a motile phenotype to neural stem cells.

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Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.


The epidermal growth factor receptor (EGFR) has been shown to play an important role in brain development, including stem and precursor cell survival, proliferation, differentiation, and migration. To further examine the temporal and spatial requirements of erbB signals in uncommitted neural stem cells (NSCs), we expressed the ligand-independent EGF receptor, EGFRvIII, in C17.2 NSCs. These NSCs are known to migrate and to evince a tropic response to neurodegenerative environments in vivo but for which an underlying mechanism remains unclear. We show that enhanced erbB signaling via constitutive kinase activity of EGFRvIII in NSCs sustains an immature phenotype and enhances NSC migration.

[Indexed for MEDLINE]

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