Format

Send to

Choose Destination
See comment in PubMed Commons below
Pediatr Crit Care Med. 2004 Jan;5(1):10-3.

Adenosine infusion for the management of persistent pulmonary hypertension of the newborn.

Author information

1
Paediatric Intensive Care Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK.

Abstract

OBJECTIVE:

To determine the effect of adenosine for the management of persistent pulmonary hypertension of the newborn.

DESIGN:

Prospective, observational case series report.

SETTING:

A single, tertiary referral neonatal intensive care unit.

PATIENTS:

Nine neonates with persistent pulmonary hypertension of the newborn requiring mechanical ventilation and inhaled nitric oxide at 20 parts per million.

INTERVENTIONS:

A continuous intravenous infusion of adenosine at 50 microg/kg/min.

MEASUREMENTS AND MAIN RESULTS:

Peripheral arterial oxygen saturation, arterial oxygen tension, invasive systemic arterial blood pressure, and pulmonary arterial pressure, estimated using echocardiography, were recorded. There was a significant improvement in arterial oxygenation tension in six of nine neonates who responded to adenosine: PaO2 increased from 66.8 (range, 47-70.5) torr (8.8 kPa) to 73.5 (range, 58.5-94.2) (p=.02) and pulmonary arterial pressure decreased significantly from 63 (range, 42.5-64.0) to 43.5 (range, 32.75-49) mm Hg (p=.002). The pulmonary to systemic mean artery pressure ratio fell from 1.27 (range, 0.88-1.5) to 0.81 (range, 0.64-0.84) (p=.002). Three neonates did not respond to adenosine infusion.

CONCLUSIONS:

The use of adenosine infusion in combination with inhaled nitric oxide may be a potentially valuable therapeutic option for the treatment of pulmonary hypertension of the newborn. Neonates with irreversible lung pathology may not respond to adenosine infusion.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wolters Kluwer
    Loading ...
    Support Center