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J Magn Reson Imaging. 2004 Jan;19(1):34-9.

Diffusion tensor imaging in the diagnosis of primary lateral sclerosis.

Author information

1
Department of Radiology, Weill Medical College of Cornell University, New York, New York 10021, USA. amu@watts.med.cornell.edu

Abstract

PURPOSE:

To evaluate the utility of MR diffusion tensor imaging in diagnosing primary lateral sclerosis (PLS).

MATERIALS AND METHODS:

Five patients who met clinical criteria for a diagnosis of PLS, and two patients with possible PLS of less than three years duration and eight normal volunteers were studied using MR diffusion tensor imaging.

RESULTS:

All seven patients showed decreased diffusion anisotropy and increased diffusion constant in the PLIC, with complete separation from a normal control group, including patients early in the course of the illness.

CONCLUSION:

Quantitative diffusion tensor imaging appears to be a useful test to detect upper motor neuron damage and hence to help to establish the diagnosis of PLS.

PMID:
14696218
DOI:
10.1002/jmri.10433
[Indexed for MEDLINE]

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