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Asian J Androl. 2003 Dec;5(4):349-52.

Effect of alcoholic extract of Lepidium meyenii (Maca) on testicular function in male rats.

Author information

1
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Postal Office 1843, Lima, Peru. iiad@upch.edu.pe

Abstract

AIM:

To evaluate the effect of the alcoholic extract of Lepidium meyenii (Maca) on the spermatogenesis in male rats.

METHODS:

In Holtzman rats, Maca alcoholic extract (5 %) was given by oral route at doses of 48 mg/day or 96 mg/day for 7 days, 14 days and 21 days. Testicular function was assessed by measurements of lengths of different stages of seminiferous epithelia and by epididymal sperm count.

RESULTS:

Ethanolic extract of Maca increased the length of stages IX-XI of seminiferous epithelium at treatment day 7, day 14 and day 21. Progression of spermatogenesis was evident only after day 21 when lengths of stages XII-XIV of seminiferous epithelium were increased; at day 7 and day 14, no important change in spermatogenesis was observed. Epididymal sperm count was increased with 48 mg/day at all times. With 96 mg/day an increase in sperm count was observed at day 7, but it was reduced at day 14 and day 21 of treatment. Serum testosterone levels were not affected.

CONCLUSION:

The alcoholic extract of Maca activates onset ant progression of spermatogenesis at 48 mg/day or 96 mg/day in rats.

PMID:
14695987
[Indexed for MEDLINE]
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