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Int J Med Microbiol. 2003 Nov;293(5):377-81.

Chlamydia pneumoniae induces the expression of inhibitor of apoptosis 2 (c-IAP2) in a human monocytic cell line by an NF-kappaB-dependent pathway.

Author information

1
Department of Medical Microbiology and Hygiene, University of Ulm, Ulm, Germany. christian.wahl@medizin.uni-ulm.de

Abstract

Members of the inhibitor of apoptosis protein family are important factors that regulate apoptotic cell death. As demonstrated both by RT-PCR and Western Blot analysis C. pneumoniae infection of the human monocytic cell line Mono Mac 6 induces the expression of mRNA and protein of the cellular inhibitor of apoptosis 2 (c-IAP2). Blocking NF-kappaB DNA-binding activity by the proteasome inhibitor MG-132 results in decrease of C. pneumoniae-induced c-IAP2 expression. Therefore, C. pneumoniae may exploit the NF-kappaB pathway to induce expression of an antiapoptotic host cell protein that may contribute to intracellular survival of the pathogen.

PMID:
14695066
DOI:
10.1078/1438-4221-00274
[Indexed for MEDLINE]

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