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Neurology. 2003 Dec 23;61(12):1814-6.

Chronic neuropathy with IgM anti-ganglioside antibodies: lack of long term response to rituximab.

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Department of Neurology, Neuromuscular Unit, Hospital de la Sta Creu i St Pau and Institut de Recerca HSCSP, Universitat Autònoma de Barcelona, Spain.


Two patients with chronic motor neuropathy, high antiganglioside antibody (AGA) titers, and a declining response to IV immunoglobulins were treated with rituximab at a standard dose. The drug was well tolerated and effectively eliminated peripheral B cells (CD20+), but AGA titers continued significantly high. No clinical improvement was detected during the 1-year follow-up.

[Indexed for MEDLINE]

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