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Antimicrob Agents Chemother. 2004 Jan;48(1):337-9.

In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides.

Author information

1
Laboratory of Immunology, Institute of Tropical Medicine, Antwerp, Belgium. yvherrewege@itg.be

Abstract

The nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 (Dapivirine) effectively prevented human immunodeficiency virus (HIV) infection in cocultures of monocyte-derived dendritic cells and T cells, representing primary targets in sexual transmission. Both drugs had a favorable therapeutic index. A 24-h treatment with 1,000 nM UC-781 or 100 nM TMC120-R147681 prevented cell-free HIV infection, whereas 10-fold-higher concentrations blocked cell-associated HIV.

PMID:
14693562
PMCID:
PMC310190
[Indexed for MEDLINE]
Free PMC Article

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